grubalo Posted May 22, 2020 Share Posted May 22, 2020 (edited) Hi, Can anyone mention some key *human* gut (large intestine) bacterial species that are considered beneficial, confirmed by peer-reviewed research? There is a lot of literature establishing links between diseases and higher or lower diversity or with particular species of gut bacteria, plus there is a lot of variation from person to person in terms of microbial composition. But, is there a consensus on some gut bacterial species that are beneficial to the body, and commonly found in anyone? Thanks! Freddy Edited May 22, 2020 by grubalo Link to comment Share on other sites More sharing options...
dimreepr Posted May 22, 2020 Share Posted May 22, 2020 If you're bovine the answer is a little more straightfoward. Link to comment Share on other sites More sharing options...
Sensei Posted May 22, 2020 Share Posted May 22, 2020 (edited) https://www.google.com/search?q=gut+bacteria+vitamins "Probiotic bacteria, members of the gut microbiota, are able to synthesize vitamin K and most of the water‐soluble B vitamins, such as biotin, cobalamin, folates, nicotinic acid, panthotenic acid, pyridoxine, riboflavin, and thiamine, in humans." https://en.wikipedia.org/wiki/Probiotic Edited May 22, 2020 by Sensei Link to comment Share on other sites More sharing options...
grubalo Posted May 22, 2020 Author Share Posted May 22, 2020 Thanks for your comment, dimreepr... it led me to this article Colonization of the human gut by bovine bacteria present in Parmesan cheese https://www.nature.com/articles/s41467-019-09303-w didnt know about that! 2 minutes ago, Sensei said: https://www.google.com/search?q=gut+bacteria+vitamins "Probiotic bacteria, members of the gut microbiota, are able to synthesize vitamin K and most of the water‐soluble B vitamins, such as biotin, cobalamin, folates, nicotinic acid, panthotenic acid, pyridoxine, riboflavin, and thiamine, in humans." https://en.wikipedia.org/wiki/Probiotic That's true, that's one good example, but a bit broad, need to check if we know what species are actually responsible.... Looking for any other good examples like this... Thanks, Sensei Link to comment Share on other sites More sharing options...
Sensei Posted May 22, 2020 Share Posted May 22, 2020 4 minutes ago, grubalo said: That's true, that's one good example, but a bit broad, need to check if we know what species are actually responsible.... Looking for any other good examples like this... Thanks, Sensei In this article you will find the names of the species: https://en.wikipedia.org/wiki/Human_gastrointestinal_microbiota Link to comment Share on other sites More sharing options...
grubalo Posted May 22, 2020 Author Share Posted May 22, 2020 7 minutes ago, Sensei said: In this article you will find the names of the species: https://en.wikipedia.org/wiki/Human_gastrointestinal_microbiota yes... but its Wikipedia...which I love, but Im after peer reviewed sources... Link to comment Share on other sites More sharing options...
Sensei Posted May 22, 2020 Share Posted May 22, 2020 (edited) 4 minutes ago, grubalo said: yes... but its Wikipedia...which I love, but Im after peer reviewed sources... Once you have the specie name (from Wikipedia article, like I said), you can search net for keyword and get peer-reviewed articles.. Edited May 22, 2020 by Sensei Link to comment Share on other sites More sharing options...
dimreepr Posted May 22, 2020 Share Posted May 22, 2020 25 minutes ago, Sensei said: Once you have the specie name (from Wikipedia article, like I said), you can search net for keyword and get peer-reviewed articles.. It's not that simple, we eat more than just grass... Link to comment Share on other sites More sharing options...
StringJunky Posted May 22, 2020 Share Posted May 22, 2020 2 hours ago, grubalo said: yes... but its Wikipedia...which I love, but Im after peer reviewed sources... Check the references in Wiki. That's how you know the sources. Link to comment Share on other sites More sharing options...
Strange Posted May 22, 2020 Share Posted May 22, 2020 3 hours ago, grubalo said: yes... but its Wikipedia...which I love, but Im after peer reviewed sources... https://en.wikipedia.org/wiki/Human_gastrointestinal_microbiota#References Link to comment Share on other sites More sharing options...
grubalo Posted May 22, 2020 Author Share Posted May 22, 2020 3 hours ago, Strange said: https://en.wikipedia.org/wiki/Human_gastrointestinal_microbiota#References yeah... but these are not always peer reviewed sources. Like with the gut bacteria list, it was sources from this "textbook" http://www.textbookofbacteriology.net/normalflora_3.html but the textbook it self doesnt provide clear references to the sources. If you look, Bacteroides fragilis, one of the species listed, this species is rather a pathobiont, rather than a benefical bacteria. Anyway, subtle difference, but I was hoping to hear from anyone who knew of a study showing a list of strictly beneficial, comensal, bacteria. Anyway, I just wanted to see what species people came up with... Link to comment Share on other sites More sharing options...
CharonY Posted May 22, 2020 Share Posted May 22, 2020 This question is actually quite tricky when it comes to humans. The reason being that it is difficult to associated specific bacteria (or even communities) with overall better outcomes. There are often so many confounding factors that makes it difficult to pinpoint benefits of particular bacteria. In addition, it is possible that much of the benefits is based on community actions, which might further be influenced by interactions with the host and diet. To the best of my knowledge we basically have a set of bacteria that we know to be common gut bacteria with little pathogenic potential and there is the assumption that that they at least confer passive benefits (e.g. inhibiting pathogenic bacteria). There are some suggestions based on a specific conditions (e.g. looking at the gut community of folks with certain health issues or by extrapolating known metabolic activities that could be beneficial). However, so far we do not actually have a good grip in understanding what gut flora is actually really healthy and how to get it. The effects of pre- and probiotics are not very reproducible, for example. Link to comment Share on other sites More sharing options...
grubalo Posted May 23, 2020 Author Share Posted May 23, 2020 7 hours ago, CharonY said: This question is actually quite tricky when it comes to humans. The reason being that it is difficult to associated specific bacteria (or even communities) with overall better outcomes. There are often so many confounding factors that makes it difficult to pinpoint benefits of particular bacteria. In addition, it is possible that much of the benefits is based on community actions, which might further be influenced by interactions with the host and diet. To the best of my knowledge we basically have a set of bacteria that we know to be common gut bacteria with little pathogenic potential and there is the assumption that that they at least confer passive benefits (e.g. inhibiting pathogenic bacteria). There are some suggestions based on a specific conditions (e.g. looking at the gut community of folks with certain health issues or by extrapolating known metabolic activities that could be beneficial). However, so far we do not actually have a good grip in understanding what gut flora is actually really healthy and how to get it. The effects of pre- and probiotics are not very reproducible, for example. Yes, that was my thinking. I found one table, in this guide by a testing company https://www.diagnosticsolutionslab.com/sites/default/files/u16/GI-MAP-Interpretive-Guide.pdf page 19. It lists some commensal/normal bacteria. But, searching for some of these, for example, if you look at Bacteroides fragilis, in this table listed as a commensal bacteria with important role, it is also associated with disease, depending on the context https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176045/ So I guess its up to the bacteria been in the right level... overgrowth /dysbiosis would make any bacteria problematic... although I dont know if this is backed by research Link to comment Share on other sites More sharing options...
StringJunky Posted May 23, 2020 Share Posted May 23, 2020 2 hours ago, grubalo said: Yes, that was my thinking. I found one table, in this guide by a testing company https://www.diagnosticsolutionslab.com/sites/default/files/u16/GI-MAP-Interpretive-Guide.pdf page 19. It lists some commensal/normal bacteria. But, searching for some of these, for example, if you look at Bacteroides fragilis, in this table listed as a commensal bacteria with important role, it is also associated with disease, depending on the context https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176045/ So I guess its up to the bacteria been in the right level... overgrowth /dysbiosis would make any bacteria problematic... although I dont know if this is backed by research And location. Link to comment Share on other sites More sharing options...
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