Dwargal Posted April 19 Posted April 19 Hello, I've had an idea, and I'd like to know what the problems are. The body is capable of initiating the Krebs cycle, i.e. energy generation via 3 metabolic pathways. Glycolysis (glucose → pyruvate) Beta oxidation (lipid → AcetylCOA) And via the degradation of amino acids (most notably Alanine, Serine, Glycine) via transamination. I'd like to focus on the latter. Why can't we give diabetics lots of these amino acids and Alanine aminotransferase capsules or something similar. I know that the body uses glucose a lot, especially for the brain, as it's still the main source of energy, but can we engage a forced functioning of energy formation (ATP) by transamination via the KREBS cycle? This would avoid too high a concentration of glucose, and hence hyperglycemia. What's more, I believe I saw in a study that ALT2, the enzyme responsible for alanine transamination, is more prevalent in diabetics, which could be perfect for my reasoning. In the diagram below, we can see that the pyruvate formed is converted into glucose, why? Because pyruvate can be forced into the Krebs cycle instead of into gluconeogenesis, can't it? These are questions I'm asking myself, I'm clearly lacking in knowledge and I'd love your help in understanding the problems and why this hasn't been done. Thanks you very much Have a good day
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