Hydrogen as medicine...

[Externet]

Greetings.

What do you know about using hydrogen gas; 2-4% as medical treatment  ?  What is your opinion ?

-Yes, I have search engines too; am asking if you knew something about it.-

[Eise]

2 hours ago, Externet said:

What do you know about using hydrogen gas; 2-4% as medical treatment  ?  What is your opinion ?

That you should be careful with fire...

[exchemist]

8 minutes ago, Eise said:

That you should be careful with fire...

Heh heh. I have a nitroglycerine spray on my bedside table.😁For medical purposes.

Edited Tuesday at 07:17 AM by exchemist

[exchemist]

5 hours ago, Externet said:

Greetings.

What do you know about using hydrogen gas; 2-4% as medical treatment  ?  What is your opinion ?

-Yes, I have search engines too; am asking if you knew something about it.-

No. I see various references and even a Wiki article, but everything seems to be by researchers with Chinese names. In view of the huge number of bogus and/or bad Chinese papers flooding the science literature these days I would be more convinced if I could see some European or N American researchers were working on it. 

But maybe someone else here knows about this. 

[studiot]

2 hours ago, Externet said:

Greetings.

What do you know about using hydrogen gas; 2-4% as medical treatment  ?  What is your opinion ?

-Yes, I have search engines too; am asking if you knew something about it.-

Since you have quoted  less than 5% of a mixture you must have had a source of information to start from.

So for instance what is in the rest of the 96% ?

And how is it applied ?

Please post it here for comment.

[exchemist]

7 minutes ago, studiot said:

Since you have quoted  less than 5% of a mixture you must have had a source of information to start from.

So for instance what is in the rest of the 96% ?

And how is it applied ?

Please post it here for comment.

The lower explosion limit for hydrogen in air is 4% by volume.   

[studiot]

Just now, exchemist said:

The lower explosion limit for hydrogen in air is 4% by volume.   

Useful, but doesn't answer my questions.

A google search of the use of hydrogen in diving gases is interesing.

Here is an authoritative publication.

https://pubmed.ncbi.nlm.nih.gov/38507913/

 

 

Edited Tuesday at 12:11 PM by studiot

[Externet]

3 hours ago, studiot said:

So for instance what is in the rest of the 96% ?

And how is it applied ?

Please post it here for comment.

Hello studiot.  Air on plain nasal-cannula;  attached ---> https://www3.nhk.or.jp/nhkworld/en/shows/2050163/

[TheVat]

Seems to reduce oxidative stress and apoptosis.  < 4%.

 

https://pmc.ncbi.nlm.nih.gov/articles/PMC5731988/#:~:text=H2 mediates oxidative stress,gas in the human body.

It was previously considered physiologically inert in mammalian cells, and was not thought to react with active substrates in biological systems. Recently, H₂ has emerged as a novel medical gas with potentially broad applications. Dole, et al. first reported the therapeutic effects of H₂ in 1975 in a skin squamous carcinoma mouse model [10]. Thereafter, inhaling high pressure H₂ was demonstrated as a treatment for liver parasite infection-induced hepatitis [11]. In 2007, Ohsawa and colleagues discovered that H₂ has antioxidant properties that protect the brain against I/R injury and stroke by selectively neutralizing hydroxyl radicals (·OH) and peroxynitrite(ONOO^-) [1].

To date, H₂ preventive and therapeutic effects have been observed in various organs, including the brain, heart, pancreas, lung, and liver. H₂ mediates oxidative stress and may exhibit anti-inflammatory and anti-apoptotic effects [12–14]. H₂ not only provides a safe and effective disease treatment mechanism, but also prompts researchers to re-visit the significance and benefits of medicinal gas in the human body. This review summarizes recent progress toward potential preventive and therapeutic applications of H₂ and addresses possible underlying molecular mechanisms...

 

 

[exchemist]

13 hours ago, TheVat said:

Seems to reduce oxidative stress and apoptosis.  < 4%.

 

https://pmc.ncbi.nlm.nih.gov/articles/PMC5731988/#:~:text=H2 mediates oxidative stress,gas in the human body.

It was previously considered physiologically inert in mammalian cells, and was not thought to react with active substrates in biological systems. Recently, H₂ has emerged as a novel medical gas with potentially broad applications. Dole, et al. first reported the therapeutic effects of H₂ in 1975 in a skin squamous carcinoma mouse model [10]. Thereafter, inhaling high pressure H₂ was demonstrated as a treatment for liver parasite infection-induced hepatitis [11]. In 2007, Ohsawa and colleagues discovered that H₂ has antioxidant properties that protect the brain against I/R injury and stroke by selectively neutralizing hydroxyl radicals (·OH) and peroxynitrite(ONOO^-) [1].

To date, H₂ preventive and therapeutic effects have been observed in various organs, including the brain, heart, pancreas, lung, and liver. H₂ mediates oxidative stress and may exhibit anti-inflammatory and anti-apoptotic effects [12–14]. H₂ not only provides a safe and effective disease treatment mechanism, but also prompts researchers to re-visit the significance and benefits of medicinal gas in the human body. This review summarizes recent progress toward potential preventive and therapeutic applications of H₂ and addresses possible underlying molecular mechanisms...

 

 

Yes this is one of the Chinese papers.

[CharonY]

This is outside my expertise but a cursory reading suggests that similar to quite a few other antioxidant treatment options, they benefits might not be very high.

On 1/28/2025 at 3:23 AM, exchemist said:

In view of the huge number of bogus and/or bad Chinese papers flooding the science literature these days I would be more convinced if I could see some European or N American researchers were working on it. 

I would be a bit careful regarding these statements. It is true that in recent times retractions from Chinese groups have increased, but I will also say that on average their work is more scrutinized. I am sure the numbers have changed, but about a decade ago the retraction rate of US was just below that of China, yet there wasn't a similar sense of suspicion. In general, the research community has boomed in size and the cycle of publish or perish has accelerated to ridiculous levels. There is a clear distinction between rock stars who publish monthly or even more frequently and the old backline scientists who still personally scrutinize all the data sets delivered by students. That process alone takes longer than for the rock stars to throw out a paper.

To summarize my rant a bit- I would be careful to single out specific countries, even if suspicions are warranted. There is a general issue (IMO) of research quality and it is also very evident in Western countries.