Metabolic potential

[Conceptual]

If one looks at a cell during the cell cycle, the metabolic oxidation potential will increase when the cell is actively dividing. The reason this occurs is because of the change within the cellular membrane potential, i.e, lowers. The lowering of the cell membrane potential makes the inside of the cell membrane less negative. This causes the hydrogen bonding potential within the cell water to increase. This, in turn, will increase the electrophilc potential of the cellular water.

 

Molecular oxygen is also electrophilic and is the terminal electron acceptor of the metabolism; oxygen will form water. With the electrophilic potential of the cell water slightly higher due to the ion pump reversal, this will increase the electrophilic potential of the output water. The dissolved oxygen will also become more electrophilic. The net effect is an increasing rate of electron flow toward the terminal electron acceptor.

[Bio-Hazard]

uhh. Ok. Wrong area.. or is this something you want to discuss?

[Mokele]

Flat out wrong. There is no evidence that the charge across the membrane alters during division, and furthermore, during cell division, most active metabolic processes are stopped. Even if there *was* the influx you claim, it would be tiny compared to the normal cellular oxygen consumption during interphase.

[Conceptual]

I am not talking about cell division. I am talking about the increased metabolic activity leading up to cell division. The unsaturation of the cell membrane makes the reversal of the potassium channels increase, thereby lowering the cell membrane potential. The higher ATP flux into the cell membrane is due to more sodium leaking back in. These changes parallels the increase in cellular metabolism and the increase in ATP production. The alterred membrane potential changes the potential within the cell's water.

[Mokele]

And it wouldn't be more reasonable to assume that, say, oxygen was entering because the cell was using it up at a continuous rate, thereby creating a continual loss on one side of the membrane that would result in continual diffusion inwards?

 

Is there any empirical evidence for this claim?

 

Mokele

[Conceptual]

If one looks at the production of ATP within the cell during cell cycles it steadily rises (with a few blips) toward and during mitosis. The ATP production rate of the mitochondria is a direct measurement of the rate of metabolism. The amount of oxygen being consumed by the higher rate of metabolism has to increase to explain the increasing ATP output. The metabolic proteins within the mitochondria are the same, during this ATP rate increase only their rate of reaction have increased. This means electrons are flowing faster down a electron gradient potential toward a terminal electrophilic acceptor (oxygen). If one increase the electrophilic potential of the terminal electron acceptor, the rate will increase. This is provided for by the increase in the cell's aqueous H potential (electrophilic potential increases within the cell).