shryocdj Posted April 21, 2006 Share Posted April 21, 2006 is it the case that you cannot conventionally nitrate ferrocene because the Fe is too good of a nucleophile compared to the ring? Link to comment Share on other sites More sharing options...
Tartaglia Posted April 23, 2006 Share Posted April 23, 2006 Although the iron atom is a good nucleophile for some electrophilic aromatic substituions it is unlikely to be the case in nitration. For instance Friedel Krafts acylation will almost certainly occur by formation of a Fe-C(O)R moiety and the acyl group will attack the ring in an endo fashion. Any likely nitrating conditions, even as mild as using for example [NO2][bF4] will almost certainly oxidise the ferrocene to the ferrocinium ion [Fe(eta-C5H5)2]+. This electron poor nature of this cationic species will then make electrophilic attack extremely unlikely Link to comment Share on other sites More sharing options...
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