mk_2007 Posted November 29, 2007 Share Posted November 29, 2007 what is a signal anchor in a protein?.... Link to comment Share on other sites More sharing options...
CharonY Posted November 29, 2007 Share Posted November 29, 2007 Usually this refers to a specific signal sequence that mediates the translocation and insertion of the protein into the membrane of the ER. Link to comment Share on other sites More sharing options...
mk_2007 Posted November 29, 2007 Author Share Posted November 29, 2007 but, then what is the difference between a signal anchor and a GPI modification site? Link to comment Share on other sites More sharing options...
CharonY Posted November 30, 2007 Share Posted November 30, 2007 Both are structurally as well as functionally unrelated. A signal anchor is both a signal sequence for the translocation as well as the anchor itself. Proteins that are to be attached in the membrane with a GPI anchor first need an N-terminal signal peptide, that is cleaved during the translocation of the protein, and a C-terminal site, the GPI-modification site onto which the GPI-moiety is post-translationally coupled. In other words the GPI modification siteonly only serves as a recognition site for the coupling of the GPI-anchor, but is not involved in translocation, nor does directly attach to the membrane. Link to comment Share on other sites More sharing options...
Recommended Posts
Create an account or sign in to comment
You need to be a member in order to leave a comment
Create an account
Sign up for a new account in our community. It's easy!
Register a new accountSign in
Already have an account? Sign in here.
Sign In Now