Genomics problems

[souhar]

1) Methylation of K9 of histone H3(by an enzyme (SUV39H1) is associated with heterochromatization and gene silencing.It has been reported that methylation of H3 by other enzymes can lead to transcriptional activation.With a detailed ans specific example explain how methylation can lead to opposite effects?

 

2)suppose that X-activation were not a random process but always led to the inactivation of the X chromosome derived from the father.what effect would you expect to have on the phenotype of females.