minas Posted May 1, 2008 Posted May 1, 2008 When somebody is studying the phenomenon of viruses ,he can see that when viruses are not coming in contact with a host organism, they are a sum of chemical compounds that not fulfill the criteria to be considered as life.While on the other hand they start reacting with a host, or in other words they start making chemical reactions with the compounds of the host,they become alive.The same thing happen with prions ,which are proteinaceous compounds that while they react with proteins of the host, they become alive in a way... Lets hypothesize that we make the hypothesis that:No living organism is possible to remain unchanged structurally.Lets hypothesize that this rule is principal in nature and nothing could go beyond it or prove that it is untrue. What would that mean to the way that we see the world? First of all lets make clear what we mean: An organism that would remain unchanged structurally dyring a very small period of time,would be considered as not living for that period. When we say unchanged we mean of course that there are not taking place chemical reaction inside it.Maybe there is a single cell inside an organism that is unchanged,but the rest of the cells are changing. We say then that this organism has a dead cell.,but the organism as a whole is alive.Maybe this cell would be able to regain life if it react with the appropriate signals. But maybe not. If we want to see the consequences of our hypothesis in the nature we meet the question:what is the least that can be considered as life?For example, a mitochondrion can be considered life according to what we said, but a simple chemical molecule cannot,unless it reacts with another molecule or substance.At the moment of the reaction these two substances are the least that is considerd life.So, a simple chemical reaction as long as it happens ,is the simpliest form of life, or else, the sparkle of life.That means that the superior organisms as well as all the organism is a summation of chemical reactions. The advantages of the hypethesis that we made is that we can explain successfully the prions and the viruses. Another important consequence of the hypothesis is this:Living creatures are the sum of their chemical reactions as we said.While they are getting older,they are suffering a process that is called aging.They are changing especially structurally.Obviously they are getting different.That means that the chemical reactions that are composing their body,are different from that that were before.If the chemical reaction were remaining unchanged forever,then the body would be the same,and that means that the body would stay forever young and forever alive. Lets see now a simple chemical reaction A+B—}C+D.Lets consider that C and D are gases and are expelled from the place of the reaction.The quantity of A and B will get lesser and lesser because they are becoming C and D,Or else they are suffering a chemical transformation. Lets see now another chemical reaction:A+B---}C+D--}E+F Lets consider that E and F are gasses.That means that the quantities of A,B,C,D will be lowering unless we put in the mixture exactly the quantities of A and B that is being transformed into C and D every moment.So there is an exact amount, as well as exact rhythm of adding A and B that would keep the reaction unchangeable.Lets consider now a very simple organism that is composed from the reactions :A+B--}C+D--}E+F…………--}Y+Z.Lets say that A and B are food supplements and Y and Z are compounds expelled from the organism.Of course the real organisms are much more complicated.If that organism eat theoretically a certain amount of food in acertain way, then the reactions of this organism would remained the same forever.[C,D,E,F……are all compounds of the organism.].If we didn't give the exact food ,then the reaction would change ,dependently on the how far we are from that ideal food .In the same manner we can say that all living organisms are a sum of chemical reactions that start with digestion,and end with the waste products of metabolism. As a result we can say that in a theoretical basis,if an orgasism eated exactly a certain amount,quality and quantity of foods in acertain way,then it could prevent the changing of its reactions and as a result it could prevent the aging process,expanding its lifespan.Of course this is something very difficult to happen in real life because there are numerous things that plays their role and of course things are not that simple. One important clue that suggests that what we said is true, is the recent discovery that living organisms that follow a calorie restricted diet,can expand their lifetime, in some cases as long as 60 per cent.This is not a proof that what we said is true,but it is positive to find that the changing of caloric menu has as a result a change in the lifespan.Perhaps a certain diet causes an ever greater expansion.It remains to be proved………….. The new hypothesis also says that life existed before the first cell,in the form of chemical reaction. Scientists have accepted that life was originated from a single cell,which was the first cell on earth, and composed the first thing that was a form of life. The evolution of this cell had as a result the formation of life the way that we know and see today. A problem with this idea is that, as we know, if we had just a single cell in earth right now, and out of it there was nothing, then not only this would not lead to the formation of more complicated forms of life,but this single cell soon would be dead.Despite of that,most scientists accept the single cell theory.The new theory that we introduced claims tha tit was not necessary to be a first single cell to start the evolutionary process that would lead to life as we know it today, but says that life preexisted , because even a single chemical reaction is a form of life.The creation of the first cell actually is the result of the existence of life. Lets see now another problem: In the beginning, life on earth was simplier than today. That means that there was a system of chemical reactions that gave its place to a more complicated one.This sounds a bit strange because if a system of chemical reactions does not get energy from outside, leads to an equilibrium state. If we accept that our new theory is true, means that there had to be an external source of energy{probably the large quantities of energy that comes everyday on earth from the light of the sun that lead not only to the survival of the first forms of life, but also to their survival of the first forms of life, but also in their evolution. As we said, living organisms are a summation of chemical reactions.What happens now when they die? There is a disorder in a system of reactions (for example brain necrosis, which means that in a large number of neural cells there is a stop in the reactions that happen there) that lead in a chain reaction way to a disorder in other reactions and then in others and so on.The final result is that there is a necrosis in the whole body, in a chain reaction way. This means that if somebody with a magic way made all the chemical reactions of the body started working simultaneously,(or else there was an arousal of all the reactions and all were working again),we woud not have the chain reaction leading to death again, but the organism would gain life again.The question is with which way we would stimulate all the reactions simultaneously.This means that the source of this energy, would give the appropriate energy to the whole volume of the dead cell, with the right timing.One idea is the use of an appropriate form of electromagnetic waves. 1)Imagine that with the help of a sourse of light we cultivate in a way,some chemical reactions in a small place.After a period of time,they are getting more and more complicated.Lets hypothesize that someday the whole system becomes extremely complicated.We could not see nothing more but a mixture of colours and shapes.This is life.But human is a part of this complicated system which means that he sees thing in a mirror like way,because he is in the system.so it is very difficult for him to see life in an objective way.2)Nature does not promote a certain form of life,but what we see,is the result of the sum of the reactions that happened through history. It is a big mistake not to mention that organisms that are programmed with the property of motion,have specific ch. reactions for that.This means that if these reactions are not used,the whole organism is facing a serious problem.so it is very unhealthy for someone not to exersize. entropy of life 1)what is the difference between a man that is alive and a man that is dead?In both cases the body is consisted from the same elements and compounds.But in the first case these compounds are reacting with each other and the structure of the body changes every moment.In the second case the chemical reactions of the body are lead to an equillibrium and so the composition of the body remains unchanged.The structure of a dead man cannot change if there are not microorganisms in its environment. 2)The property of reproduction in living beings that are chemical reactions seems to actually be a result of the energy that forces the chemical reactions to continue happening.Life continues because chemical reactions continue.Reproduction seems to be one of the most ancient properties. 3)The relativity of entropy What happens with the ntropy of living systems that are chemical reactions?The energy that comes externally on earth in the form of light could explain the lowering of entropy.However ,if in the beggining there where 2 or 3 reactions and after a while there are more and more ,and more complicated, seems that the entropy of the whole living system on earth or else nature, is raising.But remember that previously we said that human is not a neutral observer of things, but he is changing together with the system.This confuses him.What impact has that?It means that if humans entropy is raising slower than whole living natures entropy ,he will think that his entropy is lowering.Its something like relativity of motion.One exaple is this :Imagine a large number of birds that are flying one next to other to the same direction.If we tell them to fly one far from the other,so the group will start separating, the entropy of the system will start raising.Imagine also that there are three birds that are very close to each other,somewhere in the group.If they separate with less speed than the others and we consider these 3 birds as a system,the systems entropy will actually lower relatively with the whole system of the birds. the illusion of life 1)living organisms normally are not dying because the chemical reactions that are composing them are continuing happening.if we analyze all these reactions we will have a very good view to their homeostasis.As we said we are seeing the world from the inside , or else in a mirror like direction, because we our selves are part of things, so we appreciate things from its results.We think that homeostasis is a very magical and perfect mechanism, because we are the result of homeostasis, but the theory that we analyzed says that homeostasis simply is the cataloge of the chemical reactions that are still happening, and just because they keep happening, the organism is alive. 2)the complex organic compounds that are composing living creatures probably are the results of many years of reactions, or else they are the fingerprints of the reactions from the beginning of all the reactions till today. 3)because human is a very complicated system of reactions that all depend from each other, its very loggical to say that it is almost impossible to treat compeletely a chronic disease with a single drug.The human body is not a car that we fix the part that is wrong and everything is ok.Instead, its reactions are so complicated, that (unless the illness is caused by a foreign agent e.g. a microbe, or by that lack of a substance that can be replaced), if there is a problem with a reaction this will lead to a chain reaction way problem to other reactions of the body as well.This mechanism is responsible for chronic diseases.The only way to treat compeletely this disease is to put back the initial reaction with the problem the way it was.Every other method will reduse symptoms, but not heal.Or it may theat a problem and create another.A good example for this is the treatment of high blood pressure or cholesterol.This are much more complicated that we though, that ever with the proper treatment of high blood pressure or cholesterol, we are not talking about healing, but for statistically significant improvement.Some studies also shows that there is no decrease in mortality even with the treatment of the risk factors.Another good example are rheumatic diseases.No complete cure exists.Drugs have many side effects.One hole is closed, and another is opened. Even in major diseases there is a big dissosiation between the pathogenetic mechanisms that are discovered and treatments.This diference will continue growing if we dont realize that the mechanism that organism works is more complicated. 4)lets come now to the position to answer if the spores that some microorganisms forms(e.g. cryptobiosis,anhydrobiosis etc) are living forms.If their metabolism is not zero, if it exists but it cant be detected because it is so weak, then they dont differ in anything from the other organisms.If their metabolism is absolute zero, then the answer gets more complicated.The fact is that it doesnt matter what it is, because the question is useless.Life as we see it is simply the result of the chemical reactions on earth.As we said ,we are part of the system and we dont realize it, but if we were alien forms of life for example, and we were watching the earth from outer space, then we would see only a very complicated network of reactions that are becoming more and more because of the energy of light.This system would have different structural forms, colours, etc.So, what happens with the spores is that because they face very unfriendly conditions ,the certain chemical reactions stop happening or they are lowering their rate.According to our definition, they are not life, but what is life?Life seems to be more an invention of us,or else a term that we use to describe anything that looks like us.There is not such a thing as life, its an illusion.An organism is the reactions that we see, and we think they are something amazing because we see them separately from all the other reactions that are happening in the world.We judge them from their reult, which is that they become like us.We are a part of the reactions that are happening as well, and while we see organisms that look like us, we think they are independent creatures, but actually they cant be separated from the whole soup of reactions.The spores are becoming as they were before because their reactions start happening, and they start looking like us.There is not such a thing as homeostasis.So tthe existence of their reaction gives the illusion that we called life. 5)Another implication of the theory is that because the sum of the chemical reactions is a chain, it means that the cause of a disease maybe come from the organ that has the symptoms, but maybe not.An initial problem causes its irregularity, but depends of the vulnerability of each organ to see in which organ the symptom will be seen, because all the reactions communicate with each other, and when a problem exists its like a volcano and we dont know where will it explode.For example a psychic disorder can cause a problem from the liver for example
pioneer Posted May 1, 2008 Posted May 1, 2008 When a virus is outside a cell it is dead. What makes it come alive in the cell is equilibrium hydrogen bonding. When the virus enters the cell, it separates into pieces. The DNA goes here, this enzyme goes there, the protective coat may go into the recycle bin, etc. These pieces are not intelligent. They are simply moving toward an equilibrium place in the grid. Once everything is in place, with the leg over here and the arm over there, it appears to come to life, working in a very integrated way The arms and the legs are all tweaking the same grid, so they can coordinate from a distance and create the impression they are alive, in spite of being part solid and part hydrogen grid ghost (not a ghost but gaps that connect). But eventually all the pieces come back together so it can die again and leave the cell. It is a strange life-form, dead when together, but alive when all in pieces. But this is simply due to the spreading out allowing it to use the cell's hydrogen grid to make the necessary hydrogen bonding tweaks, so it can come alive like a disjointed puppet, but with all parts on strings that are wired into the same control device. The virus is weird. It sort of like if a human were dead. Then someone cuts off you arms, legs and head and you come alive. One arm is chopping onions. The other arm is feeding the head the soup to see if it needs more salt. One leg is rocking the baby in baby's room, the other leg is tapping to the beat of the music in the spare room, while the torso is napping in the sofa. Progress is being made toward dinner. This would seem alive, but really weird. Someone tries to help this weird person by re-attaching the limbs and head to the torso, and it dies. The cell discards all the dead attached carcasses but it leaves the disjointed life in place.
immortal Posted May 3, 2008 Posted May 3, 2008 When somebody is studying the phenomenon of viruses ,he can see that when viruses are not coming in contact with a host organism, they are a sum of chemical compounds that not fulfill the criteria to be considered as life.While on the other hand they start reacting with a host, or in other words they start making chemical reactions with the compounds of the host,they become alive.The same thing happen with prions ,which are proteinaceous compounds that while they react with proteins of the host, they become alive in a way... Well many biologists would put viruses as the bridge between nonlife---> life I would categorize them as true living organisms based on following points using the definition of life. We call something as life if it does the following basic things:- 1. Metabolism - living things have to metabolize because they have to reduce entropy. In viruses the protein coat (i.e. capsomeres) are arranged in a icosahedral symmetry which helps them to stay in the minimum possible energy. So IMO viruses don't have to metabolize and they have evolved ways to maintain themselves in the right stable configuration. 2. Sense the environment - as we all know that viruses have information(proteins) in them to bind to their specific receptors of the host so they are sensing the environment. 3. Replication - Is self-replication is the criteria for a cell to be alive? I think still we don't know why do we need heredity or why do we have to pass on our information? Yes even prions can be considered as alive because they can sometimes cross species barriers by changing its conformation, they can be passed on to the offspring through the ovum and they have a prion determining factor which can change the other proteins to its same kind with help of a chaperone. Like other micro-organisms they can be infectious or symbiont with the host depending on the configuration it takes after it has crossed the species barrier. For example:- people(including myself) have been eating sheeps from past times and no ill effects have been found but suddenly people(excluding myself) who eat cows are at the risk of getting Creutzfeldt's-Jacob disease. In some organisms they can act as temporary adaptations where the environment changes and again gets normal this can be done by changing the proteins into an inactive state and activating it when the conditions get normal again.
lucaspa Posted May 6, 2008 Posted May 6, 2008 When a virus is outside a cell it is dead. What makes it come alive in the cell is equilibrium hydrogen bonding. Would you give it up with the "hydrogen bonding"? It's been demonstrated over and over again that life is much more complicated than "hydrogen bonding". When somebody is studying the phenomenon of viruses ,he can see that when viruses are not coming in contact with a host organism, they are a sum of chemical compounds that not fulfill the criteria to be considered as life.While on the other hand they start reacting with a host, or in other words they start making chemical reactions with the compounds of the host,they become alive. That's not quite it. When a virus invades a host cell, it uses the host cells protein and DNA/RNA making processes to make virus proteins and DNA/RNA. So the virus does not "start making chemical reactions". Viruses do not have metabolism on their own: they use the metabolism of the host. As just one example, viruses have no means of breaking down food for energy. The host cell has all the anabolic enzymes and the means to produce ATP. Viruses are the ultimate parasites. They have stripped down what is required to be a parasite to the minimum, which means they cannot metabolize or reproduce on their own. Strictly speaking, by the definition of life, an entity must be able to metabolize and reproduce. I'm not going to be strict, because at some point the discussion of whether viruses are alive or not becomes a meaningless philosophical discussion. I would say "don't bother". Viruses do what they do and there is no profit in expending energy debating whether they are "alive" or not.
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