fate of intron

[asaroj27]

after splicing in hnRNA during post transcriptional modification what is the fate of intron? If they don't have any information in terms of protein then what is the role of intron ? kindly give me some idea.

[MedGen]

Well some of them also code for siRNA's and miRNA's so they are transcribed/spliced, but I'm not sure of the mechanisms for that. Otherwise, IIRC, they are earmarked for degradation.

[jimmydasaint]

From a quick scan, and this is by no stretch of the imagination complete, it seems that some introns code for snoRNA's as well as the types of RNA's specified by MedGen.

 

A couple of interesting references, though the second is a Letter and seems rushed for publication:

 

Intron-mediated RNA interference and microRNA (miRNA).

http://www.ncbi.nlm.nih.gov/pubmed/17981704

 

and

 

Fugu lntron Oversize Reveals the Presence of

U1S snoRNA Coding Sequences in Some

lntrons of the Ribosomal Protein S3 Gene

 

http://genome.cshlp.org/cgi/reprint/6/12/1227

 

Others can advance the knowledge here. The microRNA seems to interfere with the expression of mRNA with complementary nucleotide sequences. The snoRNA seems to be small nucleolar RNA with the following function:

 

Small nucleolar RNAs (snoRNAs) are a class of small RNA molecules that guide chemical modifications (methylation or pseudouridylation) of ribosomal RNAs (rRNAs) and other RNA genes (tRNAs and other small nuclear RNAs (snRNAs))

 

http://en.wikipedia.org/wiki/SnoRNA

[MedGen]

It makes sense that the snoRNA's are derived from rRNA genes as these are the targets of snoRNA, and they also all appear in the nucleolus. The rRNA is transcribed and the small and large units "put together" here, but obviously only in eukaryotes.