TLR7/8 Ligand: Imidazoquinoline/R848...Can anybody provide an MSDS?

[QIMR1]

The thread title says it all. I have searched my little heart out trying to track down an MSDS for this compound. If anybody can link me to an MSDS I would be very grateful.

 

Thanks

[jimmydasaint]

These guys used something called Imiquimod:

 

Small anti-viral compounds activate immune cells via the TLR7 MyD88−dependent signaling pathway

 

Hiroaki Hemmi1, Tsuneyasu Kaisho1, Osamu Takeuchi1, Shintaro Sato1, Hideki Sanjo1, Katsuaki Hoshino1, Takao Horiuchi1, Hideyuki Tomizawa2, Kiyoshi Takeda1 & Shizuo

Correspondence should be addressed to Shizuo Akira sakira@biken.osaka-u.ac.jp

 

 

The imidazoquinoline compounds imiquimod and R-848 are low-molecular-weight immune response modifiers that can induce the synthesis of interferon- and other cytokines in a variety of cell types. These compounds have potent anti-viral and anti-tumor properties; however, the mechanisms by which they exert their anti-viral activities remain unclear. Here we show that the imidazoquinolines activate immune cells via the Toll-like receptor 7 (TLR7)-MyD88−dependent signaling pathway. In response to the imidazoquinolines, neither MyD88- nor TLR7-deficient mice showed any inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of dendritic cells. Imidazoquinoline-induced signaling events were also abolished in both MyD88- and TLR7-deficient mice.

 

http://www.nature.com/ni/journal/v3/n2/full/ni758.html

 

Now by looking up Imiquimod, I found the following, probably because I lead a sad and meaningless life,

 

IMIQUIMOD (R837) Safety Data Sheet

 

Date: 09-05-05 Date of printing: 10-05-05 Page 1 of 2

 

 

1. Name of substance/preparation and company

1.1 Commercial product: IMIQUIMOD (1(2-Methyl-propyl)-1H-imidazol [4,5-c] quinolin-4-amine, R-837)

Cat.-No.: tlrl-imq,

1.2 Company: CAYLA SAS- InvivoGen Corp.

5 rue Jean Rodier BP 4437 3950 Sorrento Valley Blvd, suite A

31 405 Toulouse Cedex 04 France San Diego, California 92121, USA

Tel. ++33 (0)5 62 71 69 391 858 457 5874

Information obtainable from: ++33 (0)5 62 71 69 391 858 457 5874

This product is for laboratory use only and is not intended for human or animal diagnostics, therapeutic or clinical uses....

 

http://www.invivogen.com/MSDS/MSDS_imiquimod.doc

 

If this was close enough as an analogue for an MSDS for the original compound would you please enlighten us with the background of how and why it is used.

[John Cuthber]

I don't know where you are, but in the EU it's a requirement that the manufacturer/ supplier can give you a msds.

Where did you get the stuff from and can they help you?

[CharonY]

Hmm gah. I am not sure whether anyone produces them anymore. (Commercially that is).