Ageing

[Techne]

Ageing (from wiki):

Is characterized by the declining ability of cells to respond to stress, increasing homeostatic imbalance and increased risk of aging-associated diseases. Because of this, death is the ultimate consequence of aging.

 

Why do organisms age (wiki again):

Aging is believed to have evolved because of the increasingly smaller probability of an organism still being alive at older age, due to predation and accidents, both of which may be random and age-invariant. It is thought that strategies which result in a higher reproductive rate at a young age, but shorter overall lifespan, result in a higher lifetime reproductive success and are therefore favoured by natural selection. Essentially, aging is therefore the result of investing resources in reproduction, rather than maintenance of the body (the "Disposable Soma" theory[2]), in light of the fact that accidents, predation and disease will eventually kill the organism no matter how much energy is devoted to repair of the body. Various other, or more specific, theories of aging exist, and are not necessarily mutually exclusive.

 

Recent scientific discoveries are however challenging this understanding of ageing.

Prevailing Theory Of Aging Challenged: Genetic Instructions Found To Drive Aging In Worms

 

"We were really surprised," said Stuart Kim, PhD, professor of developmental biology and of genetics, who is the senior author of the research.

 

Kim's lab examined the regulation of aging in C. elegans, a millimeter-long nematode worm whose simple body and small number of genes make it a useful tool for biologists. The worms age rapidly: their maximum life span is about two weeks.

 

Comparing young worms to old worms, Kim's team discovered age-related shifts in levels of three transcription factors, the molecular switches that turn genes on and off. These shifts trigger genetic pathways that transform young worms into geezers. The findings will appear in the July 24 issue of the journal Cell.

 

The question of what causes aging has spawned competing schools of thought. One side says inborn genetic programs make organisms grow old. This theory has had trouble gaining traction because it implies that aging evolved, that natural selection pushed older organisms down a path of deterioration. However, natural selection works by favoring genes that help organisms produce lots of offspring. After reproduction ends, genes are beyond natural selection's reach, so scientists argued that aging couldn't be genetically programmed.

 

The alternate theory holds that aging is an inevitable consequence of accumulated wear and tear: Toxins, free-radical molecules, DNA-damaging radiation, disease and stress ravage the body to the point it can't rebound. So far, this theory has dominated aging research.

 

But the Stanford team's findings told a different story. "Our data just didn't fit the current model of damage accumulation, and so we had to consider the alternative model of developmental drift," Kim said.

 

The scientists used microarrays - silicon chips that detect changes in gene expression - to hunt for genes that were turned on differently in young and old worms. They found hundreds of age-regulated genes switched on and off by a single transcription factor called elt-3, which becomes more abundant with age. Two other transcription factors that regulate elt-3 also changed with age.

 

To see whether these signal molecules were part of a wear-and-tear aging mechanism, the researchers exposed worms to stresses thought to cause aging, such as heat (a known stressor for nematode worms), free-radical oxidation, radiation and disease. But none of the stressors affected the genes that make the worms get old.

 

So it looked as though worm aging wasn't a storm of chemical damage. Instead, Kim said, key regulatory pathways optimized for youth have drifted off track in older animals.Natural selection can't fix problems that arise late in the animals' life spans, so the genetic pathways for aging become entrenched by mistake. Kim's team refers to this slide as "developmental drift."

 

"We found a normal developmental program that works in young animals, but becomes unbalanced as the worm gets older," he said. "It accounts for the lion's share of molecular differences between young and old worms."

 

Kim can't say for sure whether the same process of drift happens in humans, but said scientists can begin searching for this new aging mechanism now that it has been discovered in a model organism. And he said developmental drift makes a lot of sense as a reason why creatures get old.

 

"Everyone has assumed we age by rust," Kim said. "But then how do you explain animals that don't age?"

 

Some tortoises lay eggs at the age of 100, he points out. There are whales that live to be 200, and clams that make it past 400. Those species use the same building blocks for their DNA, proteins and fats as humans, mice and nematode worms. The chemistry of the wear-and-tear process, including damage from oxygen free-radicals, should be the same in all cells, which makes it hard to explain why species have dramatically different life spans.

 

"A free radical doesn't care if it's in a human cell or a worm cell," Kim said.

If aging is not a cost of unavoidable chemistry but is instead driven by changes in regulatory genes, the aging process may not be inevitable. It is at least theoretically possible to slow down or stop developmental drift.

 

"The take-home message is that aging can be slowed and managed by manipulating signaling circuits within cells," said Marc Tatar, PhD, a professor of biology and medicine at Brown University who was not involved in the research. "This is a new and potentially powerful circuit that has just been discovered for doing that."

 

Kim added, "It's a new way to think about how to slow the aging process."

 

If ageing is pre-programmed, it should theoretically be possible to reprogram genetic software to make you live longer. All the software is there to make you live for longer, the trick is now to discover which signaling pathways need to be tweaked and how to manipulate these pathways.

[bascule]

Well, clearly you've found the Singularity juju. Congratulations.

 

I think negligible senescence is obtainable. However it's a little more than us being "programmed" to die. Aging has many causes and all of them would have to be addressed before we could reach a state of negligible senescence. Also to reach such a state you'd need to live a healthy lifestyle including caloric restriction and abstaining from alcohol/tobacco/other unhealthy things.

[Mr Skeptic]

I think that it is possible to slow aging, and theoretically possible to prevent it. However, there are many aspects to aging that need fixing, and such fixes could have other problems (such as drastically increased risk of cancer).

[Diocletian]

Don't forget that the human carrying capacity is well over its limit; thus, realistically, death can never be prevented because eventually we'll undergo a J-crash because of resource depletion and people will start dying anyway. Good nutrition is a large part of the growing and rehabilitating-of-body process and there's not enough to go around as it is.