Green Xenon Posted September 2, 2009 Share Posted September 2, 2009 Hi: Will continuous exposure to small amounts of lipopolysaccharide render the immune system unresponsive to it? If the immune system gets used to LPS, then it will no longer mount an inflammatory response towards it. Thanks, Green Xenon Link to comment Share on other sites More sharing options...
GDG Posted September 2, 2009 Share Posted September 2, 2009 Hi: Will continuous exposure to small amounts of lipopolysaccharide render the immune system unresponsive to it? If the immune system gets used to LPS, then it will no longer mount an inflammatory response towards it. Thanks, Green Xenon Yes, it is possible to induce tolerance to LPS. See, e.g., A. Draisma et al., "Endotoxin tolerance does not limit mild ischemia-reperfusion injury in humans in vivo" (2009) Inate Immunity (epub); and A.E. Medvedev et al., "Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression." J Immunol (2000) 164:5564-74. Whether this would be a good idea for therapy is a different matter... Weigh the odds of experiencing toxic shock vs. the probability of having continuous bacterial infections. Link to comment Share on other sites More sharing options...
georgeskohler Posted November 14, 2009 Share Posted November 14, 2009 what about antibodies against LPS? will there be some adaptive immune response? Link to comment Share on other sites More sharing options...
CharonY Posted November 15, 2009 Share Posted November 15, 2009 The point is that LPS elicit strong immune responses and thus inflammatory responses. Link to comment Share on other sites More sharing options...
georgeskohler Posted November 15, 2009 Share Posted November 15, 2009 so the innate immune response is all that matters? Link to comment Share on other sites More sharing options...
Magdalene Posted November 4, 2011 Share Posted November 4, 2011 hello there are many bacteria G- in our organism which are stimulate our resistance, so it happened all the time:)if will be very big dose it cause much more strong immune response, we dont know where is the limit... of course we could do many tests. Link to comment Share on other sites More sharing options...
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