The wobble hypothesis

[Genecks]

What do you guys think of the wobble hypothesis.

I'm reading wikipedia and it says there is similar thermodynamic stability.

So, I guess this means the process can be done.

But how exactly is this process being done?

Have any experiments been done to show how and why?

I'm calling it a fit, push, and release pattern.

 

Then again, it's still a hypothesis...

 

Does it affect the tRNA's release from the E site at all?

Edited November 29, 2009 by Genecks

[CharonY]

The hypothesis was formulated in the 60s. Since then wobble base pairing has become an often observed and known phenomenon.

[Genecks]

Yes, but have there actually been any studies on the varying physical processes that make it happen?

[CharonY]

If you mean whether there have been measurement of thermodynamic stability of wobble base pairs, then the answer is yes. The physical forces involved are essentially the same as for normal base pairing though the resulting geometries are slightly different.