Guys please help I have a very simple question !

[Shadar]

Guys I have a problem in understanding a discussion with my fellow class mates. He said that "Fact is, supplementing with AKG won't do squat unless you are using something like a membrane permeable ester theoretically. The metabolic intermediates exported from the beta-cell mitochondria into the cytosol have the insulin-releasing signal."

 

I know he is wrong because I readed some studies which I know go against what he said. But is he really wrong ? I asked my teacher he told me to follow up these two links for help but I still don't get it.

 

http://www.ncbi.nlm.nih.gov/pubmed/19502541

 

 

 

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCH-4J026P4-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1160166844&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=15ab9dd0034e6fad1d22bcd3819e829d

 

How do I tell him hes wrong ?

 

 

 

I am sorry if my english is not sound, as it is not my first language

 

And once again, please I would really appreciate some help

[Proteus]

Your teacher probably didn't understand, because the abstracts don't contain a reference to AKG. If those articles do mention AKG, it's parenthetically.

 

Either how, if you're diabetic AKG is no replacement for insulin.

 

"Diabetics who have been prescribed insulin therapy are highly benefitted by AKG. Insulin helps cells to use up glucose for energy production, and AKG enhances the functioning of insulin. Therefore diabetics can maintain their sugar level by taking less external insulin."

 

http://ezinearticles.com/?Alpha-Keto-Glutarate-and-the-Krebs-Cycle&id=1639827

 

Consult your doctor if you want to change doses of insulin.

 

If you use it for bodybuilding:

 

"Enrichment of a whole-protein–based formula with α-ketoglutarate did not improve protein metabolism or decrease muscle catabolism after major abdominal surgery."

 

http://linkinghub.elsevier.com/retrieve/pii/S0899900702008444

 

According to this article, it only works when combined with arginine:

 

"AKG supplements (15 grams per day for 5 months) have been shown to improve growth rates in small children. The AKG supplements resulted in elevated concentrations of anabolic (growth) hormones and amino acid metabolites, including insulin-like growth factor 1 (IGF1), glutamine and glutamate. In another study of healthy men, AKG given at 10 grams per day resulted in a 20-30% elevation in insulin (another anabolic hormone), which were not observed with supplementation of either Arginine or alpha-ketoglutarate alone."

 

http://www.ironmagazine.com/review58.html