Toadie Posted February 4, 2010 Share Posted February 4, 2010 Hi all- I was reading about psilocybin in the Erowid vaults, and it says: "The ED50:LD50 ratio is 641 according to the NIOSH Registry of Toxic Effects; compare this with 9637 for vitamin A, 4816 for LSD, 199 for aspirin and 21 for nicotine" Am I missing something or is that ratio backwards? Wouldn't that mean a user would have to kill themselves 641 times over to facilitate any psilocybin-induced effects? The way it's written, the effective dose is 641 times greater than the lethal dose, right? Am I missing something or should the ratio be LD50:ED50? Thanks Link to comment Share on other sites More sharing options...
CharonY Posted February 5, 2010 Share Posted February 5, 2010 Indeed. The therapeutic index is normally given as LD50:ED50. To nitpick: it does not necessarily that it would be 641 times the chance of getting killed (or getting killed half the time) as the the Dose:response relationship does not have to be linear (it rarely is, actually). Link to comment Share on other sites More sharing options...
Toadie Posted February 5, 2010 Author Share Posted February 5, 2010 I figured - Just wanted to illustrate my point. Thanks, in any case! Link to comment Share on other sites More sharing options...
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