CCR7 expression by dendrtic cells

[ccr7?]

Hi,

I'm studying monocyte-derived DC populations that stimulate Th1, Th2 and Th17 T cell differentiation, but I cant seem to find literature about the expression of the chemokine receptor CCR7 in these DC populations. i'm not sure if it is just generally expressed by mature DCs. Does anyone known when CCR7 is expressed?

[jimmydasaint]

I don't know if these are relevant but you can cross-reference:

 

Subsets of murine CD4+ T cells localize to different areas of the spleen after adoptive transfer. Naïve and T helper 1 (TH1) cells, which express the chemokine receptor CCR7, are home to the periarteriolar lymphoid sheath, whereas activated TH2 cells, which lack CCR7, form rings at the periphery of the T cell zones near B cell follicles. Retroviral transduction of TH2 cells with CCR7 forces them to localize in a TH1-like pattern and inhibits their participation in B cell help in vivo but not in vitro. Thus, differential expression of chemokine receptors results in unique cellular migration patterns that are important for effective immune responses.

http://www.sciencemag.org/cgi/content/abstract/sci;286/5447/2159

 

However, the papers are relatively old. I assume you know all about this one as well:

http://journals.pasteur.ac.ir/JIMMUNOL_2001/vol167-n4/1862.pdf

 

Also this effort:

Background: The chemokine receptor CCR7 is required for the migration of dendritic cells (DC) into lymph nodes, thereby mediating T-cell priming and the induction of immune responses. Oxidatively modified low density lipoprotein (oxLDL) is considered as a pivotal contributor to atherogenesis. In fact, oxLDL has been suggested to act as an antigen which promotes Th1-cell priming characterized by a specific pro-inflammatory cytokine response. It was previously demonstrated that Th1 cytokine levels are enhanced in atherosclerosis: Moreover, a specific set of T-cell receptors has recently been identified in atherosclerotic lesions. We here investigated whether CCR7-deficiency influences oxLDL induced DC-dependent T-cell priming, thereby reducing atherosclerotic plaque development

http://circ.ahajournals.org/cgi/content/meeting_abstract/116/16_MeetingAbstracts/II_1