Down-regulation of gene expression

[jbreinho]

Hi everyone! new to the boards! just have a quick question

 

 

I've seen examples of irreversable enzyme inhibitors causing down-regulation of gene expression of certain genes which causes problems with production of that enzyme once the enzyme inhibitor ceases to be in the system.

 

 

My question, is there any articles which are examples of this that you can think of off the top of your head?

 

I need to find sources for a paper I am writing.

[CharonY]

I may be a bit slow today but I am not quite sure what you are describing. What mechanism is it that you are looking for. The fact that the inhibition of an enzyme affects gene regulation or that the inhibitor of enzyme activity may also affect (in addition to the enzyme inhibition itself) regulation of genes?

Are you thinking of autoregulation (i.e. the target is the gene of the enzyme in question)? There are several possible mechanisms, but I would need more details.