gentr Posted January 6, 2011 Posted January 6, 2011 I have very little experience in the field of genetics and would really appreciate your help. This is a highly-acclaimed paper, published in a very reputable journal; however, I have been told that there are some issues with it. Do you see what could be improved? Thanks in advance! Genetic variants in TPMT and COMT are associated with.pdf
CharonY Posted January 6, 2011 Posted January 6, 2011 Could you provide the reference and abstract, please?
timo Posted January 6, 2011 Posted January 6, 2011 (edited) Well, I was brave enough to open the pdf: http://www.nature.com/ng/journal/v41/n12/abs/ng.478.html (you can/should probably delete the attachment now) Edited January 6, 2011 by timo
CharonY Posted January 7, 2011 Posted January 7, 2011 (edited) Thanks Timo! Just by a rough overview (really hardly reading), it appears to me that they did not consider multiple hypothesis testing. Or at least I could not see it. But on this level I cannot really say that it is really heavily flawed otherwise (but I would need to read in more detail to really be sure on anything). Edited January 7, 2011 by CharonY
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