rubal Posted March 10, 2011 Share Posted March 10, 2011 http://users.path.ox.ac.uk/~seminars/waldmannlibrary/Paper%2017.pdf Control of Regulatory T Cell Development by the Transcription Factor Foxp3 Can we go over the summary and a brief discussion into this article please. Would really appreciate it. Thank you! Link to comment Share on other sites More sharing options...
jimmydasaint Posted March 20, 2011 Share Posted March 20, 2011 Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however,about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inammatory syndrome in humans and mice, is specically expressed in naturally arising CD4 regulatory T cells. Furthermore, retroviral gene transfer of Foxp3 converts naıve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4 regulatory T cells. Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells. Link The immune system has T cells which 'takes out' lymphocytes that would fight the body itself. The T cells are called regulatory T cells. We have found a gene, called Foxp3 which controls how the regulatory T cell develops into a CD4 strain from naive T cells. In humans and mice where this gene is 'knocked out' or faulty, the body's lymphocytes fight against the body itself causing inflammation, or swelling (like what happens in arthritis when the joints swell up). The Foxp3 gene seems to be a transcription factor and helps DNA inside the regulator T cells to effectively become RNA. This makes sense to me. What more would you like to discuss? Link to comment Share on other sites More sharing options...
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