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linkage disequilibrium


readytogo

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  • 2 years later...

Dear all,

 

I am wondering if please somebody could take the time and explain the background and reason to how and why exactly effective population size can be estimated with Linkage disequilibrium?

I know what LD is, and Hill (1981) postulated that Ne can be estimated using it because the variance of the disequilibrium or correlation of gene frequencies is a known function of population size.

However I am not sure how that function looks like, and WHY it is a function of pop size.

 

Any advice woud be greatly appreciated!

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