linkage disequilibrium

[readytogo]

Can someone explain why I am getting negative d' values using DNAsp? The D, D' and R values are all negative and I have no idea why!

 

Please can someone reply?

 

Thank you x

[Arete]

What sort of loci are you looking at, and what sort of sampling have you undertaken (as in population level - across phyla)?

[PaulM84]

Dear all,

 

I am wondering if please somebody could take the time and explain the background and reason to how and why exactly effective population size can be estimated with Linkage disequilibrium?

I know what LD is, and Hill (1981) postulated that Ne can be estimated using it because the variance of the disequilibrium or correlation of gene frequencies is a known function of population size.

However I am not sure how that function looks like, and WHY it is a function of pop size.

 

Any advice woud be greatly appreciated!