protein biosynthesis

[bsl9811]

Hello, I have a few questions in my homework and I dont know where to go to get the answers. I have looked for books on protein synthesis, biochem texts, cant find the info.

Protein secondary structure questions:1. How does secreted protein biosynthesis differ from that of cytosolic proteins? From lysosomal proteins?

 

2. How do proteins fold?

 

3. What is the role of glycosylation in protein folding?

 

4. Where are glycosylated proteins found?

 

[PrayingMantis.]

Hello! I don't know what type of answer I am able to give you...

 

1) Proteins can be intracelular o extracelular, if they are going to be secreted (extracelular, for working outside of the cell) they follow a pathway that is called "secretory pathway", which involves their transformation and modification inside some organelles (like ER, GA, vesicules...etc). With this information you can advance in your answer! (see what happens in each organelle).

 

2) The anwser is: by their own! The aminoacid sequence extended (also know as the primary structure) contains the information to let the protein to fold in 3D and perform its function. If you want to go further, you can search for hydrofobic effect and weak interaction between amino acid side chains.

 

3) and 4) See where glycosilation takes places (which organelle) and imagine...!

 

If you need more information, just ask!

 

I hope this can help you!

 

Regards from Spain!