Myeloblastic leukemia Question Help regarding different types of Myelocytes/Myeloblasts

[Angela1]

Greetings,

 

I am having a lot of trouble finding the correct answer to this question after reading about them in my book still.

 

The question asks:

 

A patient with acute myeloblastic leukemia might have a very high bone marrow concentration of:

 

neutrophilic myelocytes

basophilic myelocytes

eosinophilic myeloblasts

colony-forming unit erythrocytes--THIS WAS MARKED WRONG

neutrophilic stab cells

 

I am very lost at which one would increase? Help would be appreciated.

[Psycho]

Diagram

 

Assuming this diagram is correct, AML mutation occurs within the Myleoblast before differentiation occurs and then excess clones of this cell being formed, however all your other options are differentiated from this cell, implying they would be reduced rather than increased.

 

Colony-forming unit erythrocytes are definitely reduced as this is a key symptom of the disease, however I can't workout which one would be increased.

 

What would be increased is the number of progenitor cells and myeloblasts, but that isn't one of the answers, are you sure the question is correct.

 

AML

Myeloblasts

Edited October 16, 2011 by Psycho

[Angela1]

Diagram

 

Assuming this diagram is correct, AML mutation occurs within the Myleoblast before differentiation occurs and then excess clones of this cell being formed, however all your other options are differentiated from this cell, implying they would be reduced rather than increased.

 

Colony-forming unit erythrocytes are definitely reduced as this is a key symptom of the disease, however I can't workout which one would be increased.

 

What would be increased is the number of progenitor cells and myeloblasts, but that isn't one of the answers, are you sure the question is correct.

 

AML

Myeloblasts

 

Thank you for replying! Hmm, you made good points...This was the question. I am wondering if to go with the only selection that had myeoblasts.