Major Help Needed! How to determine Km (Michealis constant) in a biochemistry problem?

[Angela1]

Greetings to all,

Question states: The cytochrome P450 system of liver in normal individuals has a capacity (Vm) to oxidize approximately 10 nmol of drug X per minute per gram of liver. When the concentration of drug X in the liver is 2um oxidation products are formed at the rate of 4 nmol/min/g of liver. What is the Km of cytochrome P450 for this drug?

 

Two answer choices were 5 nM or 3 uM. The correct answer is 3 uM.

 

I am totally lost on how to do this problem. Can someone please help?

 

 

[Psycho]

Link

 

There is an explanation of how to find Km and you can rearrange the equations to find Km without drawing the graph.