viral genome

[Ghaz]

can anyone tell me what will happen if a virus enters intact within a host cell without releasing its genome ?

[CharonY]

Depending on how the cell gets into the cell (e.g. whether via endocytosis) I would assume that common degradation pathways such as ERAD or endosomal degradation take care of the virus.

[Ghaz]

will the progeny virus form.I mean will their replication take place?

Depending on how the cell gets into the cell (e.g. whether via endocytosis) I would assume that common degradation pathways such as ERAD or endosomal degradation take care of the virus.

[CharonY]

It won't be able to replicate if it cannot at some point expose its genetic material to its host. Some infection pathways actually require the intact virus to be internalized, but at some point the nucleic acid (be it RNA or DNA) will be delivered to the host and eventually translated. If the host does not produce the material required for virus assembly, there will be no propagation.