Piperidine extraction

[skwiff]

will it be possible to extract this from black pepper using white spirit or acetone as i dont realy want to be using DCM...

 

 

 

sorry for the spelling mistake ^^ its ment to be piperine

Edited January 21, 2012 by skwiff

[Suxamethonium]

I wiki-ed it to find out it's structure- but I read a bit on the preparation and it is suggested to remove the alcohol from the alcoholic extract, wash the residue with sodium hydroxide and dissolve the remaining residue in ethanol, to which the compound is suppost to crystalise from. However, this has not been cited, so I don't know how accurate it is.

 

Out of interest, why do you wish to avoid DCM?

[skwiff]

mainly because i dont have much money to buy DCM ^^ acetone and white spirit are cheap and easier to obtain ^^ i know i can get DCM on ebay and i might do that next time i get paid ^^ but atm im running a mini trial with both white spirit and acetone using 125m of both solvent to see what woul happen

[Suxamethonium]

If you have a simple distillation set up you can get cheap DCM from DCM paint stripper... It is literally DCM mixed with a gel to make it stick to the wall lol. Its 87% here in australia, and its like $20AUD for 500g... it's obviously not going to be reagent grade after a simple distillation, but it wille be more than satisfactory for an extraction.

 

Edit: As for acetone and white spirirt, they will probably work, but will also bring through a lot of less desired compounds- that may be why wiki has the other method suggested?

Edited January 23, 2012 by Suxamethonium

[skwiff]

If you have a simple distillation set up you can get cheap DCM from DCM paint stripper... It is literally DCM mixed with a gel to make it stick to the wall lol. Its 87% here in australia, and its like $20AUD for 500g... it's obviously not going to be reagent grade after a simple distillation, but it wille be more than satisfactory for an extraction.

 

Edit: As for acetone and white spirirt, they will probably work, but will also bring through a lot of less desired compounds- that may be why wiki has the other method suggested?

 

DCM has been banned for use in paint strippers here in the UK (an the EU) so that opition is out of the window^^

[Suxamethonium]

:S I really hope that doesn't happen here. The other thing you could do if the acetone etc doesn't work, is make chloroform using the haloform reaction (acetone and hypochlorite) and use that to perform the extraction.

[skwiff]

:S I really hope that doesn't happen here. The other thing you could do if the acetone etc doesn't work, is make chloroform using the haloform reaction (acetone and hypochlorite) and use that to perform the extraction.

 

im not making chloroform again ^^ not after i nearly knocked myself out. it smells nice tbh ^^

[Suxamethonium]

Well... I'm not sure if this will work as well as chloroform, but ethyl chloride and ethylene dichloride are still used for a few things- perhaps these are cheaper and more readily available to you? And if you got them cheap and they don't work for this at least they are handy solvents to have around

 

Edit: I was sticking with the chlorides because recrystalisation is as easy as letting the solvent evapourate- but you may find that poly ethylene glycols (PEGs) might be useful (or maybe even dioxane or THF might based on solutbility in ether). Idk... this is mostly just speculation so maybe try with what you have and hope for the best? Do you have anything to confirm what your end compound is? GCMS, NMR, IR etc.

Edited January 25, 2012 by Suxamethonium