Protein Kinase

[VOGA]

Hi, I was wondering if anyone has any knowledge about Focal Adhesion Kinase (protein tyrosine kinase 2). I am doing a basic report on it, that needs information on 1. Where it is found, 2. Its structure, 3. Its Mechanism of Action, and 4. Role of enzyme in human disease/therapy. I mainly need guidance to 1. and 3 if anyone has any sites or papers that would be appreciated. I did some research myself and found alot of cancer research and the role of this enzyme, but I cannot seem to find where it is found (surprisingly), but I am assuming Focal Adhesion is located in the cytoskeleton, while the protein kinase complex is found in the extracellular matrix (But I do not know forsure). Anywho, any help would be much appreciated.

 

Thanks