IGF1 receptor competition

[jacksna]

I read a study stating that some of this combined were morepotent than when used alone. I went toschool for health and human performance so my biochem is not very deep. My understanding was that all of thesecompeted for the same receptors. How canthey be more potent if that is true. Maybe I just don’t get it.

 

LR3-IGF1

 

Des (1-3) IGF-1

 

([Arg³]IGF-I)

 

Des (1-3) MGF

 

MGF- Ct24E

 

MGF

 

(Des(1-6)IGF-II)

 

IGF-1

 

IGF-2

 

[Leu²⁴][Ala³¹]IGF-I

 

[Leu²⁴]IGF-I

 

([Leu⁶⁰]IGF-I)

 

LR3-IGF2,

 

[Leu²⁷]IGF-II

 

[Arg⁶]IGF-II

 

 

I sell a medical biologic that contains IGF2 is why I ask. thank you for your help.

 

 

 

NM I figured out my answer. The question looks stupid now in hind sight. Thank you.

[vampares]

IGFBP3 is the carrier protein. This carrier would limit amount of all IGF in circulation and saturation inhibit the introduction of more IGF. Using a combination of IGF's would lead to the activation of more receptors (which may or may not be absolutely specific) provided the IGF is not an endogenous antagonist.