Vaccines that work in vitro but not in vivo?

[gigi]

I know this isn't the homework help section...but those questions seemed to be a little more basic.

So a hexapeptide inhibits the activity of a virus in vitro but not in vivo. Which ones of these would be a reason?

 

1. The peptide could not be processed by dendritic cells.

2. The peptide was too complex.

3. The hexapeptide failed to activate monocytes, macrophages, and dendritic clls.

4. The peptide was too long.

5. The peptide was insufficiently complex.

6. The induced cytokine response was too weak.

7. The hexapeptide failed to activate NK cells.

8. The peptide was too short.

9. The vaccinations did not work becase T-cell epitopes were absent.

 

I'm thinking 1,3,5,8,and 9 are true reasons. but not sure.

 

any ideas on this?

[hypervalent_iodine]

!

Moderator Note

Homework is homework! Moving to the appropriate section.