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Posted

Hello folks,

I am currently working on a Simulation of the diffusion of Synapsin within

the presynaptic terminal. My current problem lies in the dependency
factor. I am using a System of PDEs.


Does anyone have empirical information on the binding rates of Syn 1 to
SVs and actin filaments? I try to make my model as realistic as
possible (using FEA and Multigrid Methods). I thought of a sort of
"Beta-Function" describing the Binding-Behavior of
Synaspin.

WhatI found was an old article on the saturation of Synapsin 1
stating that there might be a saturation at 76 +- 40 µg Syn I per ng
Vesicle. There is no indication on how the behavior changes when an
AP arrives.


I am kind of new to this, I used to study computer science, so I would
be very grateful if someone could help me out.



Sincerely yours



Heliodromus



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