hello all

 

I am new here and I hope you can help me out. I tried to do some Googling but I can't find the answer to this.

 

The difference between iso-pentane and neo-pentane is in the arrangement of the atoms, they are both 5 carbon atom, with different structure.

 

1.But why is endorphin so different from neo-endorphin? The former has about 3x the number of carbon atoms as neo-endorphin?

 

2. What's the the practical function of endorphin and neo-endorphin? Which is the one that makes us happy?

 

3. And in terms of practical purpose, which is the more important one, alpha or beta endorphin?

 

Thanks!

That is the trouble with common names; they can be a little misleading at times. Did you find these links? http://en.wikipedia.org/wiki/Neoendorphin http://en.wikipedia.org/wiki/Endorphin

Edited July 8, 201312 yr by BabcockHall

I can answer question 1) Neo-endorphin is cleaved from prodynorphin. Prodynorphin makes up endorphin so obviously the neo-endorphin is smaller than endorphin.

I can answer question 2) The neo-endorphins seem to have some kind of sensory function and regulate ADH release. The endorphins act as inhibitory pain signals you can find more information here http://www.4adi.com/objects/catalog/product/extras/SP-100053-5.pdf

For question 3) This link should give you a better answer, from reading I would say Beta-endorphin as there seems to be a lot more known about. http://www.livestrong.com/article/435947-does-exercising-give-you-endorphins/

 

 

I can answer question 1) Neo-endorphin is cleaved from prodynorphin. Prodynorphin makes up endorphin so obviously the neo-endorphin is smaller than endorphin.

 

Ouch no, that is wrong. I appreciate your enthusiasm but please do not post guessworks and proclaim them to be facts. You may confuse people.

Endorphin is a summary term for endogeneous peptides that bind to opiate receptors. What OP is referring to is probably the difference between alpha-endorphin (a specific peptide in that group) and alpha-neoendorphin.

 

The former being a peptide with the sequence Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr and the latter

Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys.

 

Proenkephalin B the precursor of alpha-neoendorphin is way larger (254 AA). Generally, peptide and protein nomenclature does not follow the same rules as other, smaller C-bodies and can be a bit confusing at times. Even worse, many have several names, depending how it was identified and characterized.

Edited September 5, 201312 yr by CharonY

CharonY is right I miss read that point but everything else was right my mistake!