CJD variants and their different symptoms?

[jsmith613]

CJD is an example of a disease caused by the misfolding of the protein PrP©

I have been researching this disease somewhat and have discovered there are several variants including sporadic CJD and variant CJD.

It appears that the different variants of the disease have different risk factors and different physiological effects. Given that they are all caused by the misfolding of the same protein - PrP© - I was hoping someone could explain to me why the physiological effects of each variant differ in some respects [including:median age of death, duration of illness and some clinical signs/symptoms]

thanks