Who is the first that found 'Heat Shock Protein 90α (Hsp90α) is a new marker for tumors'

[Jiawei Wu]

Today I read a news from website, something is similar to twitter. It announces that Tsinghua University is the first one who prove that Heat Shock Protein 90α (Hsp90α) is a new marker for tumors, and also they have already researched and designed test kit with only a drop of blood. But upon the interesting and curious motion, i found one paper which has been published in Jan of 2012. Now i am confused.

 

The address of that news as follows:

http://blog.dianlake.com/tsinghua-university-developed-only-a-drop-of-blood-test-kits-can-be-measured-a-variety-of-cancers.html

 

The address of that paper as follows:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308794/#FN2

 

someone could give me something else news?

 

 

[Amanbir Singh Grewal]

the chinese lol. heat shock protein - what is that?

[Jiawei Wu]

the chinese lol. heat shock protein - what is that?

one special protein, i am not majoring in this field, but just want to full fill my knowledge and interest. what i am concern about is that who found it first.

[janekai]

There is a paper directly linked to this published in 2009. See the following link.

 

http://www.pnas.org/content/106/50/21288.full

 

The time HSP90alpha was discovered is very likely before 2009. However, to study it as a tumor marker is a different story.

Today I read a news from website, something is similar to twitter. It announces that Tsinghua University is the first one who prove that Heat Shock Protein 90α (Hsp90α) is a new marker for tumors, and also they have already researched and designed test kit with only a drop of blood. But upon the interesting and curious motion, i found one paper which has been published in Jan of 2012. Now i am confused.

 

The address of that news as follows:

http://blog.dianlake.com/tsinghua-university-developed-only-a-drop-of-blood-test-kits-can-be-measured-a-variety-of-cancers.html

 

The address of that paper as follows:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308794/#FN2

 

someone could give me something else news?

 

 

A good question raised.

the chinese lol. heat shock protein - what is that?

I can see you have a biased brain in your head.

[turionx2]

http://en.wikipedia.org/wiki/Hsp90

 

Hsp90 blood levels that have been measured would have to be used with caution regarding wether someone has cancer or not because other than cancerous cells, physical activity also increases Hsp90 levels. An overweight and inactive person with elevated Hsp90 levels would most likely have cancer, while a healthy physically active person would most likely not have cancer, unless they lived in a polluted city.

 

http://www.ncbi.nlm.nih.gov/pubmed/18784937

Edited November 17, 2013 by turionx2

[janekai]

http://en.wikipedia.org/wiki/Hsp90

 

Hsp90 blood levels that have been measured would have to be used with caution regarding wether someone has cancer or not because other than cancerous cells, physical activity also increases Hsp90 levels. An overweight and inactive person with elevated Hsp90 levels would most likely have cancer, while a healthy physically active person would most likely not have cancer, unless they lived in a polluted city.

 

http://www.ncbi.nlm.nih.gov/pubmed/18784937

That is true. Lots of tumor biomarkers have been identified so far. Few is used for practical diagnosis purpose.

[Phi for All]

I can see you have a biased brain in your head.

 

There is no evidence to support this. Any bias you detect must stem from a different, existing organ.

[CharonY]

Cancer biomarkers are quite an issue. The problem is that cancer metabolism is (for obvious reasons) not fundamentally different from regular cells. Since we do not know very well the function and active range of any given protein in all our tissues of interest it is expected that the vast majority of identified biomarkers will be based on spurious associations and ultimately not be diagnostic.

One of the important things to keep in mind is the specificity and sensitivity of the test, while the former tends to be the big issue.

 

Even worse, even if some proteins at a given concentration range are found to be well associated with cancer, it does not necessarily provide sufficient practical information to inform on the correct therapeutic therapy.

PSA is such an example, which appeared to be a decent marker fro prostrate cancer. However, several studies indicated that early diagnosis of this type of cancer does not lead to better therapeutic outcomes. It may be more important for more aggressive forms, however.

Edited November 18, 2013 by CharonY