preventing progression to AIDS

[Tom1205]

1. people with neutropenia due to inherited defects in immune activation pathways are routinely treated with GM-CSF to stimulate bone marrow release of immune effector cells.

 

2. furthermore, GM-CSF is shown to be able to reconstitute CD4 T cells (http://www.ncbi.nlm.nih.gov/pubmed/23001765)

 

 

 

 

>>>So why can't we just treat mid-late stage HIV/AIDS patients with GM-CSF, thereby increasing their CD4 T cell count....at the same time administering the HAART to keep virus in check......perhaps this would reverse AIDS symptoms due to the increase in CD4 T cell count?

 

What do you guys think?

[Endy0816]

Looks like together it has a chance of working, GM-CSF alone though can actually increase viral activity.

 

http://jid.oxfordjournals.org/content/182/5/1531.long

 

http://www.sciencedirect.com/science/article/pii/S0165242798000877

 

I'm thinking there is more to the story, but in general looks like your thought is a good one.

[Tom1205]

@your first link.

 

oh wow. looks like someone thought of that already. they should have done a CD4 T cell count to see if it went up... even though the symptoms didn't really improve :\