MDCLS Posted March 10, 2014 Share Posted March 10, 2014 Hi All I am currently trying to analyse Rapramycin (Sirolimus).I have a DES and I am trying to extract the Raprmycin with DMSO and analyse it on the GCMS underivatised does anyone have any experience of this analysis Thanks Link to comment Share on other sites More sharing options...
John Cuthber Posted March 10, 2014 Share Posted March 10, 2014 I wouldn't even try to get that molecule down a gc column. Too big, too polar. Link to comment Share on other sites More sharing options...
hypervalent_iodine Posted March 10, 2014 Share Posted March 10, 2014 What John Cuthber said. You are not going to get that down a GC column, so please don't go and destroy one by trying. Have you thought of using LC-MS? Link to comment Share on other sites More sharing options...
CharonY Posted March 10, 2014 Share Posted March 10, 2014 Agreed, GCMS is no good. Depending on what you try to do either simple LC-UV/vis or LCMS would be much better alternatives. Rapamycin is going to contaminate the GC column badly. Link to comment Share on other sites More sharing options...
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