John Cuthber Posted June 28, 2014 Posted June 28, 2014 The reason the papers are flawed and irreproducible is that there is a (low, and slightly variable) natural level of basophil degranulation which they have ignored. It's impossible or, at least, impractical to measure a small enough increase in that rate. Obviously, a statistically significantly higher level of degranulation does mean that the material is having an effect. That's why labs do the test. This is essentially the same point that I made in the 4th post in this thread and I wonder why you are still asking about it. It is not possible to distinguish between a very small effect and no effect. They can not prove that there is "no effect" so they say there's a low effect.
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