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question from a beginner


Althalus

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Dear all,

 

I am currently using the Pubmed SNP database for my literature review. However, I got very confuse with information presented to me.

 

Each SNP has their own unique rs number, but how come when I keyed in an rs number, there are so many HGVS names for it? and they are all so different.

 

For example

 

rs4680 for COMT gene. there are 14 HGVS names

 

  • NC_000022.11:g.19963748G>A
  • NG_011526.1:g.27009G>A
  • NM_000754.3:c.472G>A
  • NM_001135161.1:c.472G>A
  • NM_001135162.1:c.472G>A
  • NM_007310.2:c.322G>A
  • NP_000745.1:p.Val158Met
  • NP_001128633.1:p.Val158Met
  • NP_001128634.1:p.Val158Met
  • NP_009294.1:p.Val108Met

Would be glad if someone can enlighten me. Thank you so much

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