Vaccines, allergies, autism and autoimmune disorders

[vinucube]

We have discussed food proteins in injected vaccines and their association with the development of food allergies.
http://www.scienceforums.net/topic/78023-direct-evidence-from-the-cdc-that-vaccines-cause-food-allergies/
http://www.scienceforums.net/topic/83698-polysorbate-80-vaccines-and-federal-allergen-regulation/?hl=polysorbate
http://foodallergycauses.wordpress.com/category/food-allergy-causes/

We have also discussed pollen proteins injected by insects and their association with the development of pollen allergy.
http://www.scienceforums.net/topic/80120-pollen-allergies-related-to-insect-bites-and-water-treatment-plants/

It is the flu season and I have been researching an ever increasing number of flu vaccine options to chose from. Trivalent/quadrivalent,
intramuscular, intradermal, jet injectors, intranasal, canine kidney based, insect based. etc. I also found that various vendors of the flu vaccine have varying amounts of ovalbumin (0-1 mcg), Polysorbate 80, gelatin, antibiotics, mercury, Triton x-100, latex etc. I digress, but do you research and choose the least contaminated flu vaccine? or do you go with the flu vaccine du jour of your provider?

In any case, the jet injector got me thinking about the injection process itself. It occurred to me that regardless of jet, intramuscular
or intradermal, the jet or needle tears through the skin/muscle and bits of skin/muscle (with skin/muscle proteins) will be deposited into the body along with the vaccine itself. We have been discussing how the adjuvants in vaccines can increase the immune response and result in more effective sensitization to the viral and food proteins in the vaccine. By the same mechanism, one could in theory expect immune system sensitization to the skin/muscle proteins that were also deposited. Once sensitized, on subsequent exposure, the immune system will attack these proteins and the symptoms can include allergic reaction, inflammation or anaphylaxis.

With vaccine injections scheduled for a kid increasing to 40-50 shots, the probability is now higher that the immune system is sensitized to skin/muscle proteins. One can therefore expect an increase in immune system related skin disorders such as eczema. Perhaps the increase in eczema over the past 40 years is related to the increasing number of adjuvanted jabs?

The major allergen in crustaceans, such as shrimp, is tropomyosin, which is a muscle protein.
My understanding is that human muscle also contain this protein - tropomyosin.

So an intramuscular vaccine shot could tear muscle cells and deposit some tropomyosin along with the vaccine adjuvants. This can result in immune system sensitization to tropomyosin.

Tropomyosin is also present in the intestine and the brain.

Maybe immune system sensitization to tropomyosin and subsequent immune system attack on tropomyosin can explain autism and autistic children having intestinal disorders such as irritable bowel syndrome and ulcerative colitis. Of course, sensitization to tropomyosin will also result in seafood allergy.

Vaccines are of course a very important tool to protect humans from dangerous diseases. With increasing vaccination, they are beginning to look like a blunt tool that causes a lot of damage. Vaccines are conceptually very simple. It is time to develop a new generation of more sophisticated vaccines that are more precise in their impact and safe.

[Essay]

Neat idea, about that sort of 'auto-immunization' occurring as a consequence of the physical process of vaccination.

However, those reactions aren't associated with vaccines (statistically, afaik), so another association might prove more insightful.

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Did you know that many of the same genes, which are associated with autism (and linked to late-stage fetal brain development), are also used for the development of the digestive system, during an earlier stage of fetal development?

 

I was not surprised then to hear how the exact chromosomal regions, containing those dual-use genes, were also subject to a novel mutational mechanism whereby rearrangements and duplications and deletions are enhanced.

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Maybe the transition from a paleolithic diet to a modern agricultural diet, as well as the transition to upright walking, is putting some pressure on those 'digestive system' genes to shift and adjust. The consequences to brain development are interesting, and are providing for even more diversity and opportunities to evolve.

 

~

[vinucube]

"However, those reactions aren't associated with vaccines (statistically, afaik), so another association might prove more insightful."

 

Kuno-Sakai H, Kimura M. Removal of gelatin from live vaccines and DTaP-an ultimate solution for vaccine-related gelatin allergy.Biologicals 2003;31:245-9. [PubMed]

The above article demonstrates that food proteins in vaccines cause the development of food allergies. So it is not a stretch to expect that tropomyosin injected with vaccines can result in development of allergy to tropomyosin. And it need not even be a vaccine. Even the Vitamin K1 shot given at birth could cause the tropomyosin sensitization.

 

The trouble with the genetic angle is how does one explain the huge increase in autism over the last two decades.

Edited September 14, 2014 by vinucube

[Essay]

"However, those reactions aren't associated with vaccines (statistically, afaik), so another association might prove more insightful."

 

Kuno-Sakai H, Kimura M. Removal of gelatin from live vaccines and DTaP-an ultimate solution for vaccine-related gelatin allergy.Biologicals 2003;31:245-9. [PubMed]

The above article demonstrates that food proteins in vaccines cause the development of food allergies. So it is not a stretch to expect that tropomyosin injected with vaccines can result in development of allergy to tropomyosin. And it need not even be a vaccine. Even the Vitamin K1 shot given at birth could cause the tropomyosin sensitization.

 

The trouble with the genetic angle is how does one explain the huge increase in autism over the last two decades.

 

Oh, sure, that reasoning wouldn’t apply to just vaccines, but to all injections….

…and hey, what about the statistics on oral vaccines?

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But as to the genetic angle:

The rise in autism does coincide closely with a radical shift in diet and lifestyle, unprecedented in evolutionary history; and autism seems to be more prevalent in regions most affected by those shifts.

 

Also, look at the infant mortality rate (over 1/3) until modern medicine came along. Many kids with these ‘problems linked to vaccines,’ such as allergies and autoimmune disorders, would not have survived long enough to contribute to the gene pool, until recently (or their parents, like me, wouldn’t have survived).

 

And, if you look at the long and broad history of infanticide, and the historical tolerance (or lack thereof) for social deviance, and the strong religious proscriptions for normative behavior, then you could see another reason why it is only recently that ‘more variant’ genes (especially those genes affecting ‘social interaction’) began surviving to reproductive age.

 

~ istm

[vinucube]

If oral vaccines are designed to defeat stomach acid and carry intact proteins to the intestine, the body will develop allergies to these intact proteins that were absorbed into the blood.

Like intranasal vaccines if the oral vaccines only cause a local infection, then it is unlikely that any protein in the vaccine will cause the development of allergies.

 

I agree that natural selection has been somewhat modified by modern medicine. However, regarding autism and allergies we are talking about their rise over the last 2-3 decades in the US.

Infant mortality has improved during this time. Infanticide is irrelevant too.

C-section birth have skyrocketed and they are a known risk factor for priming newborns to the formation of IgE mediated allergies. Autism was found to be higher among high socio-economic status areas in Southern California. Probably due to higher prevalence of elective C-section births?

So genetics alone does not seem to be able to explain it.

Edited September 15, 2014 by vinucube