3-bromopyruvate as an anti cancer drug

[Hans de Vries]

Have you heard of that compound? Some interesting studies were done that demonstrated extraordinary, highly selective anti-cancer properties of 3-BP - unfortunately patent disputes between the researcher and John Hopkins University resulted in discontinuation of research. Since then limited studies on humans have been done in Germany and Colombia albeit with highly promising results (total eradication of metastatic liver cancer in a male patient and of small cell lung carcinoma in a Colombian female patient)

 

 

[3bromopyr]

These are the big threads on 3-Bromopyruvate.

 

http://www.cancercompass.com/message-board/message/all,65701,107.htm

 

http://www.longecity.org/forum/topic/73453-is-3-bromopyruvate-3-bp-a-cancer-cure/

 

3-BP has gained significant traction ever since the publication of the results of the metastatic melanoma patient.

2 combination doses of IV 3-BP and paracetamol (aka acetaminophen) resulted in a metabolic cure in a patient who was truly terminal.

IV 3-BP is a fairly low tech technology that could allow widespread use.

 

http://www.ncbi.nlm.nih.gov/pubmed/24636230T

 

The Cancer compass forum (see above) reported yesterday that a Toronto clinic is offering C $370 IV 3-BP injections. At this price point, 3-BP could experience a wave of patient interest.

An interesting exercise is to go to the chemicalize.org website and enter the search term pyruvic acid.

Pyruvic acid / pyruvate is one of the main chemicals involved in cellular respiration-- the main energy pathway

of living things. Next scroll down and on the left of the page click "View all similar structures". This will pull up all chemicals that are related to pyruvic acid.

 

The idea here is that any chemical that is similar to pyruvic acid, though slightly different might disrupt the energy pathway

that is required (especially for cancer to live).

 

The interesting thing is that of the almost 800 results, when you look at the 130 or so that have 20 or page hits, almost all of these chemicals have anti-cancer properties! So when something is similar, though not exactly the same as pyruvic acid the molecule can fool the energy pathway and disrupt the cancer cells reliance on the glycolysis pathway. (Cancer relies about 50% on glycolysis for energy while ordinary cells only receive 10% of their energy from glycolysis)

 

It is intereesting to note that in the search above, 3-BP was an early hit. Metylglyoxal, another hit that showed up late, has recently been found to also be an anti-cancer agent in a long term clinical trial from India. (Manuka honey has large amounts of Methylglyoxal.)