Enzyme therapy - true/false?

[Tomas Hajkovsky]

Hello,

 

is it possible for large molecules of proteins - hydrolases (10 - 50 kDa) to be absorbed (in their -fully functional form) through the wall of small intestine to blood? Enzymes got to the intestine because it was protected against digestion in stomach by medicament cover.

 

If yeas, is it possible through the mechanisms of persorption by slubs, tight junctions or by random lymphocytes carrying enzymes?

 

Thank you for your answers!

[CharonY]

It would be incredibly inefficient and almost impossible to control the dosage. Typically anything larger is provided intravenously. That is why insulin (~5.8 kDa) pills are not available, for example (but there seems to be some work on it).

[Tomas Hajkovsky]

Thank you!