Aspirin synthesis

[Kenzo]

Hi,

 

Would varying the temperature of this synthesis have any effect on its yield? Normally temperature affects the reaction rate but would this question be applicable?

[hypervalent_iodine]

Depends on the exact reaction. In addition to kinetic considerations, temperature also affects equilibrium. You can also get different things out by altering the temperature and playing with thermodynamic vs. kinetic control.

 

Increasing the rate can help to improve yield when considering a constant reaction time, also.

[Kenzo]

Thank you.