Precipitation of drug in presence of SLS

[rcpatel2]

I am facing problem that my drug ranolazine is precipitated in pH 4.5 acetate buffer with Sodium lauryl sulphate anf precipitation increases with increase in concentration of SLS, while in case of pH 6.8 Phosphate buffer no precipitation of drug observed in presence of SLS

[John Cuthber]

Why is it a problem? What are you trying to do?