Negative Homotropic Effectors

[ozscience]

Hello all! I am studying for a Biochem exam and am having issues understanding how Koshland's Sequential model accounts for negative homotropic effectors. (aka, substrate binds and next substrate is less likely to bind leading to a higher cooperativity) If someone could please give me some sort of a link to a diagram or simply explain it to me that would be great! Google search is not working to well.

[BabcockHall]

You might try searching on negative cooperatively. In the book Structure and mechanism in protein science, Alan Fersht has a very brief treatment on pages 296-297 (second edition).